a Record control number 000239509300005

a ISSN 13973142

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WS 18.2

b Item number .F74 2006

a Personal name Tumgor, Gokhan.

h Medium Electronic Document

a Title Frequency of hyperuricemia and effect of calcineurin inhibitors on serum uric acid levels in liver transplanted children

c Statement of responsibility, etc Gokhan Tumgor, Cigdem Arikan, , Murat Kilic, Sema Aydogdu.

c Date of publication, distribution, etc 2006.

b Name of publisher, distributor, etc Blackwell Publishing,

a Place of publication, distribution, etc Oxford :

a Summary, etc Hyperuricemia is common after renal and cardiac transplantations, but it is rarely reported after liver transplantations. The aim of this study is to determine the frequency of hyperuricemia in children following orthotopic liver transplantation and the effects of calcineurin inhibitors tacrolimus and cyclosporine) on blood uric acid levels. Between September 1997 to January 2004, 76 liver transplantations were performed in 70 children (male/female; 39/31) at Ege University, Organ Transplantation Center (37 deceased donation and 39 live donors). Patients who had been transplanted within the last three months and patients who died within six months after liver transplantation were excluded from the study. Finally 59 patients were included in this study. Uric acid levels were measured before transplantation and after transplantation within six months intervals for two yr. In these series 17 cases had increased uric acid levels after liver transplantation (28.8%). Serum uric acid levels in both groups (tacrolimus or cyclosporine) were detected to be significantly higher than initial values at 12th months (p < 0.05). Hyperuricemia developed in eight patients receiving cyclosporine (eight of 11; 72%) whereas nine patients receiving tacrolimus developed hyperuricemia (nine of 48; 18%). However, the rate of having high uric acid levels was significantly higher in cyclosporine group compared tacrolimus group (p = 0.001, OR: 11.5, CI 95% 2.5-52.4). Uric acid levels were also significantly higher in cyclosporine group in 12th and 18th months (respectively, p = 0.003 and p = 0.003). Serum creatinine levels at 12th, 18th and 24th months were significantly higher in cyclosporine group than tacrolimus group (respectively, p = 0.009, p = 0.04 and p = 0.02). Hyperuricemia is a common complication after liver transplantation in children. Cyclosporine may cause hyperuricemia more often in respect to tacrolimus and this may be related to the impairment of renal functions. Complications developing because of hyperuricemia such as gout disease or renal calculi are quite rare in children.

a Topical term or geographic name as entry element Pediatrics

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Uric acid

a Topical term or geographic name as entry element Liver transplantation

a Topical term or geographic name as entry element Cyclosporine

g Relationship information SEP 2006, Vol. 10 Issue 6, p665-668

x International Standard Serial Number 13973142

t Title Pediatric Transplantation.

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1111/j.1399-3046.2006.00556.x